Bioengineering Seminar: Mark Cronin-Golomb

Friday, July 31, 2015
2:00 p.m.
Pepco Room (1105), Jeong H. Kim Engineering Building
Alyssa Wolice
awolice@umd.edu

Mark Cronin-Golomb
Professor, Biomedical Engineering
Tufts University

Using light to manipulate and probe biomaterials at the microscopic level

The combination of lasers and microscopes has long been an enabling technology for biomedical optics. In this talk I describe research aimed at the development of a combined optical tweezers and nonlinear scanning microscopy platform. The immediate application of this instrument is the investigation of the apparent link between stiffness of extracellular matrix and cellular differentiation in the environment of the mammary gland, with a view towards increased understanding of the development of breast cancer. The instrument will be able to simultaneously make optical tweezers based measurements of the stiffness of extracellular matrix, and use second harmonic imaging to characterize the accompanying collagen network. 

Nonlinear microscopes can also be configured for two-photon based photolithography. I present some results on the use of the nonlinear optical properties of azobenzene to write patterns in an azobenzene modified version of the silkworm silk used in much of our department’s research in tissue engineering. In this way silk scaffolds may be optically patterned to guide cells such as neurons and fibroblasts.

About the Speaker

Mark Cronin-Golomb is a Professor of Biomedical Engineering at Tufts University and has been involved in variety of nonlinear optics research, from photorefractive nonlinear optics to terahertz wave generation, to optical tweezers.

Audience: Public 

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