ChBE Seminar Series: Bramie Lenhoff

Tuesday, May 3, 2016
11:00 a.m.-12:00 p.m.
Room 2108, Chemical and Nuclear Engineering Building
Dr. Jeffery Klauda
jbklauda@umd.edu

Dr. Bramie Lenhoff
Allan P. Colburn Professor and Chair
Department of Chemical and Biomolecular Engineering
University of Delaware

The Molecular Sociology of Proteins

Protein solutions are ubiquitous in bioprocessing, structural biology and in nature, making it important to understand and predict their physical and thermodynamic properties, including formation of dense phases such as precipitates, crystals, gels and aggregates.  The anisotropic shape and chemical character of protein molecules, on which extensive information down to the atomic level is available from X-ray crystallography, add considerable complexity, especially in describing intermolecular interactions and phase behavior – the molecular sociology.  In particular, the statistical mechanics of anisotropy, including the contributions of strongly attractive interactions guided by the same mechanisms that give rise to biomolecular recognition, can lead to counterintuitive consequences.  This presentation will explore these consequences, a focus on two systems: the origins of high viscosity in solutions of monoclonal antibodies, and the structure and evolution of amorphous dense phases of proteins, such as precipitates and gels.

 

Audience: Public 

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